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Reviews of Clinical Research


 

Research Reviewed by the Faculty and Students at the National Flight Nurse Academy

Building the Evidence Base for Practice




Neuromuscular Blockade Improves Intubation Success


Eight Hour Training Course

This study conducted in San Diego County, trained approximately ¾ of practicing paramedics in rapid sequence intubation (RIS) using neuromuscular blocking agents with an 8 hour course and certification.


The target population was adult trauma victims with severe traumatic head injury (TBI), a GCS of 8 or less and transportation time of greater than 10 minutes. The medication regime consisted of midazolam for sedation, succinycholine for paralysis, rocuronium for paralysis maintenance and morphine for hypertensive stress response. A total of 249 patients meet inclusion criteria and 123 patients were entered into the trial. The indications for RSI included clenched jaw, presence of gag reflex and a combative patient. The total procedure was performed on 114 patients with success in 113 (99%) with ET intubation in 96 patients and Combitube placement in 17 patients.


Performing the procedure added 14 minutes to on-scene time and reduced the number of RSI performed by airmedical crews. The 99% success rate shows improvement over the general 84% success rate of ET intubations alone. The findings may not be generalizable to other districts due to the experience and already aggressive airway management protocols in place before the trial. For more information, see:


Davis DP, Ochs M, Hoyt DB, et al. (2003). Paramedic-administerred neuromuscular blockade improves prehospital intubation success in severely head-injured patients. The Journal of Trauma, Injury, Infection and Crticial Care, 55, 713-719. [review prepared by Andrew Reimer BSN RN]